CAR T-cell therapy for relapsed T-cell leukemia
Treatments studied
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This early-phase trial tests a lab-made immune cell treatment (CAR T-cells) aimed at T-cell leukemia that has come back or did not respond. It may help by targeting leukemia cells with a specific marker (CD7), especially in patients who failed standard treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your leukemia is T-lineage acute lymphoblastic leukemia/lymphoma that has relapsed or is refractory after treatment
- You have measurable disease after treatment (for example, abnormal cells seen in bone marrow or cerebrospinal fluid)
- Your lungs work well enough: mild or no breathing trouble (Grade 1 or less) and oxygen level above 95% on room air
- Your heart pumping function is strong enough based on an ultrasound (echocardiogram)
- You can carry out daily activities at a moderate level (Karnofsky or Lansky score at least 50)
- Your leukemia cells have very high CD7 levels (over 99%) for the anti-CD7 CAR T-cell dose
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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