Sildenafil by mouth to improve breathing in COPD
Treatments studied
Part of Lungs & breathing clinical trials.
This Phase 2 trial tests whether sildenafil tablets can improve exercise ability, shortness of breath, and heart-lung function in people with COPD. It also compares against people without COPD to better understand how sildenafil affects breathing tests.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You either have COPD or you do not—this study includes both groups
- If you have COPD: your lung test shows COPD (low FEV1/FVC after inhaler) and your FEV1 is above 30% of predicted
- If you do not have COPD: your lung test looks normal (FEV1/FVC above the cutoff) and your FEV1 is above 80% of predicted
- You must be able to safely do exercise testing, with no major orthopedic limits or other reasons you can’t be tested
- You must not have certain heart conditions that could interfere with exercise testing
- You must not be pregnant or breastfeeding, and you (if able to become pregnant) must use reliable birth control during the study
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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