Testing inhaled nitric oxide effects on lung function in COPD
Treatments studied
Part of Lungs & breathing clinical trials.
This early trial tests whether inhaled nitric oxide changes how well your lungs exchange gases during exercise in people with COPD, and compares results with healthy volunteers. It may help researchers understand lung blood-flow and breathing differences that could affect symptoms and exercise tolerance.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re 18 to 85 years old.
- If you have COPD, you must have mild or moderate COPD and meet specific breathing test results (FEV1/FVC below normal; FEV1 in the right range).
- If you have COPD, you must have smoked more than 10 pack-years in your life.
- You must not have other major heart, metabolic (like uncontrolled sugar issues), or nerve/muscle problems that can affect breathing or exercise response.
- You can’t be unable to do a bike-exercise test due to a muscle or joint injury.
- If you have COPD, you must NOT currently take oral prednisone, PDE5 inhibitors (erection-medicine like sildenafil), or use supplemental oxygen.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether inhaled nitric oxide gas can improve outcomes in people with moderate-to-severe chronic obstructive pulmonary disease (COPD). It may help reduce breathing problems by targeting how airways and blood vessels respond in the lungs.
This Phase 2 trial tests whether sildenafil tablets can improve exercise ability, shortness of breath, and heart-lung function in people with COPD. It also compares against people without COPD to better understand how sildenafil affects breathing tests.
This trial tests whether a gas called nitric oxide, breathed in through the nose or mouth, can help people with moderate to severe COPD. It could improve breathing and quality of life.
This study looks at how a measurement of inflammation in the breath (called fractional exhaled nitric oxide) relates to COPD flare-ups in people who are already using a triple inhaler therapy. It aims to find better ways to predict and manage COPD exacerbations.
This trial tests whether giving nitric oxide gas through a breathing tube can improve oxygen levels in patients with severe obesity who are on a ventilator. It may help those whose lungs are struggling due to acute respiratory failure.
This study tests how a bronchodilator (a medicine that opens airways) affects breathing and exercise in people with COPD. It aims to understand if it helps you breathe easier during physical activity.
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