Metformin to improve walking in leg artery blockage
Part of Heart & circulation clinical trials.
This Phase 3 study tests whether metformin can help people with intermittent claudication (leg pain when walking) walk farther. It compares how well metformin works on walking ability alongside standard (already recommended) heart and blood-vessel medicines.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re a Veteran between 35 and 89 years old
- You have intermittent claudication—leg pain that starts with walking and eases with rest
- You’re on your best blood-vessel and heart medicines for at least 3 months (such as a statin, anti-platelet, blood pressure control, and counseling for smoking and activity)
- Tests show blocked leg artery disease: ankle-brachial index (ABI) under 0.9, or ABI above 0.9 with other proof
- Your walking test shows limited walking (at least 50 meters on a 6-minute walk) with pain starting by 400 meters, and you’re not using a walker
- You do NOT have certain exclusions like diabetes, metformin use, severe kidney problems, or critical limb-threatening wounds
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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