Theta-burst brain stimulation for walking freezing in Parkinson’s
Part of Brain & nervous system clinical trials.
This trial tests whether a specific type of noninvasive brain stimulation (theta-burst TMS) can improve “freezing of gait,” where walking suddenly stops. It may help by targeting brain circuits involved in movement, especially if your symptoms persist despite stable medication.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a diagnosis of freezing of gait (FOG) confirmed by a movement-disorders specialist
- Your FOG questionnaire score (question 3) is at least 1
- You’re at least 40 years old
- You’ve been on the same dose of Parkinson’s-related medications for at least 2 months
- You have no seizure history (yours or a first-degree relative’s) and no recent substance abuse
- You don’t have safety issues for brain stimulation, like metal near your head that can’t be removed
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests whether atomoxetine, a drug that boosts a brain chemical called noradrenaline, can help reduce freezing of gait—a feeling of your feet being stuck to the ground—in people with Parkinson's disease. You would continue your usual Parkinson's medications during the study and undergo walking tests and brain scans to see if the drug helps.
This trial tests whether increasing the dose of levodopa or adjusting deep brain stimulation (DBS) can help reduce freezing of gait in people with Parkinson's who already have good control of other symptoms. It aims to find the best way to manage this common and frustrating problem.
This trial tests if a special type of brain stimulation (called TMS) can help people with Parkinson's disease who experience freezing of gait—when your feet feel stuck to the floor. The goal is to see if this treatment can improve walking and reduce those freezing episodes.
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