Estradiol to improve brain and reward changes in midlife women
Treatments studied
Part of Brain & nervous system, Mental health clinical trials.
This study tests whether a hormone called estradiol (given as a patch and pill) changes how the brain and body respond to reward in some midlife women with low pleasure and/or psychosis symptoms during menopause transition. It may help researchers understand whether estrogen treatment can improve mood-related “reward” function in this group.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be a 44–55-year-old woman who is going through late menopause transition and has had at least two skipped periods (and at least 60 days without a period)
- Have new or worsening low-pleasure symptoms (anhedonia) and/or psychosis-type symptoms that started when your periods became irregular
- Score high enough on screening questionnaires to show your symptoms are affecting you in a clinically significant way
- Be willing to follow the estradiol treatment plan for the study
- Be able to sign consent, follow study visits/procedures, and stay available for the full study
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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