Ticagrelor or aspirin after heart valve replacement
Treatments studied
Part of Heart & circulation clinical trials.
This trial compares two blood thinners (ticagrelor and aspirin) to see which one works better at preventing blood clots after a less-invasive heart valve replacement (TAVI). It is for people with severe aortic stenosis who also have diabetes, heart disease, or artery disease.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have severe narrowing of your aortic heart valve and are scheduled for a TAVI procedure.
- You also have diabetes, or a history of heart attack or chest pain, or blockages in leg arteries.
- You do not need long-term blood thinners like warfarin (for clots or irregular heartbeat).
- You have not had a major bleeding episode or a stroke in the last 30 days.
- You are not allergic to ticagrelor or aspirin.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether a personalized plan for blood thinners after TAVI can reduce the risk of stroke or bleeding better than the current standard of one daily blood thinner. If you've had a successful TAVI and don't need specific other blood thinners, you might be able to join.
This trial studies whether a new through-the-blood-vessel heart valve (TAVR) is safe and works well for people with severe aortic stenosis who are too risky for traditional surgery. If you qualify, you would be closely followed to check your symptoms and valve function over time.
This trial compares different methods to evaluate coronary artery disease in patients planning to have a transcatheter aortic valve replacement (TAVR) for severe aortic stenosis. The goal is to find out if a less invasive approach is as safe and effective as the standard one.
This trial tests whether a common blood pressure pill (called an angiotensin receptor blocker) can help your heart recover after a TAVR procedure. If you recently had TAVR for severe aortic stenosis and your heart muscle is thickened, this medicine might improve your long-term heart health.
This trial compares two newer types of replacement heart valves (SAPIEN 3 Ultra Resilia and Evolut FX) to see which one works better for people with severe aortic stenosis, a condition where the heart's main valve becomes narrow. If you join, you'll be randomly assigned to receive one of the two valves during your TAVI procedure.
This trial compares aspirin and clopidogrel (two blood-thinning medicines) after TAVR to see which is safer or more effective for preventing clots. You may be able to join if you recently had a TAVR for severe aortic valve narrowing and can follow the study plan.
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