Testing an early breathing device for ALS lung weakness
Part of Brain & nervous system, Hormones & metabolism clinical trials.
This study tests whether using a “pressure relaxer” (RLX) earlier can improve breathing problems caused by ALS-related weak breathing muscles. You may be placed by chance into the device group or a comparison group to see if lung function and comfort improve.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re 18 or older and have a confirmed diagnosis of ALS
- Your breathing muscle strength test is lower than expected—SNIP or MIP has dropped by 10% or more, or is under 90% of predicted if it’s your first check
- You are not currently using RLX for lung recruitment (using it only for clearing/organizing airways is allowed)
- Your lung breathing capacity (FVC) is not too low—must be 50% or higher of the predicted value
- You do not have certain serious breathing conditions or risks (like needing non-invasive breathing support, known air pocket in the lung, or current untreated tuberculosis)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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