Personalized neck radiation using a lymph node sentinel biopsy
Part of Cancer clinical trials.
This Phase 3 trial tests whether guiding neck radiation by checking the “sentinel” lymph node can target treatment more precisely in certain larynx, hypopharynx, or oropharynx cancers. It aims to improve control while potentially reducing unnecessary radiation to areas that don’t need it.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are age 18 or older with a newly diagnosed squamous cell cancer of the oropharynx (throat), larynx, or hypopharynx
- Your cancer has not spread to distant organs (M0) and involves lymph nodes only on the side(s) allowed by the study (N0 to N2b, or specific HPV+ patterns)
- You’ve had full neck scans (CT or MRI) and a PET scan showing no cancer in lymph nodes on the opposite side
- Your head and neck cancer team recommends cure-intent external-beam (chemo)radiotherapy, and if chemo is used it must be a platinum-based regimen
- You can have the sentinel lymph node biopsy under general anesthesia (the surgeon says the tumor is reachable for the tracer injection and surgery)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new way to guide radiation treatment for a type of throat cancer that is on one side only. The goal is to see if using a special scan (SPECT-CT) to map lymph drainage can help doctors decide how to treat the neck more precisely and reduce side effects.
This trial tests a safer radiation plan that may reduce dose to the opposite (other) side of the neck while still treating the cancer spread risk. It uses special mapping to guide treatment and looks at patients whose cancer is already in an involved lymph node on one side.
This trial is testing whether radiation to just the lymph nodes near the tumor is as effective as treating a larger area of the neck. It is for people with certain head and neck cancers (not unknown primary or glottic) and aims to lower side effects.
This study tests whether a personalized approach to radiation therapy after surgery, guided by a special lymph node biopsy (sentinel node biopsy), can effectively treat mouth cancer while reducing side effects. It is for people whose cancer is on one side of the mouth and has not spread to the other side of the neck or beyond.
This study checks whether a “sentinel lymph node biopsy” can help find if skin cancer in the head or neck has spread to nearby lymph nodes. It uses special dye/medicine and imaging, then removes the cancer and the sentinel node soon after scanning.
This trial tests whether giving radiation only to the specific lymph nodes that need it works as well as standard radiation for people with nasopharyngeal cancer. It aims to reduce side effects while still controlling the cancer.
Hear when a new Laryngeal Squamous Cell Carcinoma trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.