Azacytidine plus venetoclax to prevent AML coming back
Treatments studied
Part of Blood & lymphatic, Cancer clinical trials.
This trial studies azacytidine (AZA) plus venetoclax as maintenance treatment to help keep acute myeloid leukemia (AML) in first remission. It may help delay or prevent AML from returning in younger adults who cannot get a stem cell transplant right away.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have favorable-risk AML and are not planning to get an allogeneic stem cell transplant right away
- You are between 18 and 64 years old and currently in your first remission
- You finished remission induction therapy and then 3–4 cycles of cytarabine-based consolidation (high-dose or medium-dose)
- Your health status is fairly good (ECOG 0 to 3) and your heart and organ tests are adequate (bilirubin, liver enzymes, kidney function, and heart pumping strength)
- You can participate safely with the study medicines (including pregnancy prevention if applicable)
- You can understand and sign the informed consent
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests whether giving Venetoclax and Azacitidine (VA) after your first remission helps keep you in remission before a stem cell transplant. It's for people with intermediate-risk AML who are planning to have a donor transplant.
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