Preventive vaccine against Lynch syndrome cancer
Part of Cancer, Digestive system, Genetic & congenital, Hormones & metabolism clinical trials.
This trial tests a preventive vaccine made from your own immune cells (dendritic cells) that is designed to teach your body to fight off Lynch syndrome-related cancers before they develop. It may help stop cancer in people who are at high risk due to their genes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a confirmed Lynch syndrome gene change (in MLH1, MSH2, or MSH6). Age ranges vary from 35–75 for MLH1/MSH2, and 40–75 for MSH6.
- If you have had cancer related to Lynch syndrome, only certain cases (MSH6, cancer-free for over a year) are allowed. You must not have had a total or subtotal removal of your colon.
- You must have a specific genetic marker (HLA-A02.01) that the vaccine is designed for.
- You cannot have a history of most cancers, or conditions like HIV, hepatitis B or C, or syphilis. Autoimmune diseases (except some like type 1 diabetes or treated thyroid issues) are not allowed.
- Your kidneys, liver, and blood counts must be within healthy ranges. You must be in good physical condition (WHO score 0 or 1).
- You must be able to attend follow-ups and understand Dutch.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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