Preventing cancer in Lynch syndrome carriers with dendritic cell vaccine
Part of Cancer, Digestive system, Genetic & congenital, Hormones & metabolism clinical trials.
This trial tests whether a personalized vaccine made from your own immune cells can help prevent cancer in people with Lynch syndrome. You must have no history of cancer and be willing to have regular colonoscopies.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have Lynch syndrome caused by a specific gene change (MLH1, MSH2, or MSH6).
- You have never had invasive cancer (skin cancer that is not melanoma is okay).
- Your colon can be reached with a scope for biopsies.
- You agree to get a colonoscopy with biopsies every 1-2 years as part of standard care.
- You are 18 years or older.
- Your kidneys and liver function are within normal limits, and your blood counts are adequate.
- You are willing to avoid high-dose aspirin or anti-inflammatory drugs during the study.
- You are not pregnant, breastfeeding, or planning to become pregnant during the first year after treatment.
- You have not had an organ transplant and do not take strong immune-suppressing medications.
- You do not have active infections like HIV, hepatitis B, or hepatitis C.
- You can have a procedure (leukapheresis) to collect your white blood cells.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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