Stem cell transplant for aplastic anemia and bone marrow failure
Treatments studied
Part of Blood & lymphatic clinical trials.
This trial tests a stem cell transplant using a milder conditioning regimen and a drug called post-transplant cyclophosphamide to treat severe aplastic anemia and other acquired bone marrow failure conditions. The goal is to help patients achieve a functioning donor bone marrow with fewer side effects.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have severe aplastic anemia or another acquired bone marrow failure condition (like PNH, pure red cell aplasia, or amegakaryocytic thrombocytopenia).
- Your blood counts are very low (e.g., low platelets, low neutrophils, or low reticulocytes) and you may need transfusions.
- You have a donor available for a stem cell transplant and are willing to undergo a reduced-intensity transplant.
- You do not have an uncontrolled infection, severe liver scarring, or a known inherited bone marrow failure disorder.
- You are not pregnant and agree to use birth control if needed.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 2 study tests a bone marrow transplant from a closely matched related donor, plus medicine after the transplant to help prevent immune complications. It may be an option if you have severe aplastic anemia and meet specific health and lab requirements.
This Phase 2 study tests a specific type of donor stem cell transplant for severe bone marrow failure conditions, aiming to improve cure rates while reducing transplant risks. It includes people with diseases like severe aplastic anemia and certain bone marrow disorders, especially when standard transplant plans feel too risky.
This trial tests a specialized donor stem cell transplant to treat high-risk problems in the blood and bone marrow, including some cancers and non-cancers. It may help by using donor immune cells designed to better control the disease after transplant.
This trial tests whether giving children with aplastic anemia a transplant using a matched unrelated donor (a bone marrow donor who is not a family member) can help treat their condition. It aims to see if this approach is effective and safe for children who qualify.
This trial tests a new way to prepare the body for a donor stem cell transplant (allogeneic transplant) in people with severe aplastic anemia or other blood diseases. The goal is to make the transplant safer and more effective.
This trial tests whether an early bone marrow transplant from a half-matched family member or an unrelated donor can help people with severe aplastic anemia. It aims to restore the body's ability to make healthy blood cells.
Hear when a new Severe Aplastic Anemia trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.