Stem cell transplant for aplastic anemia and bone marrow failure
Treatments studied
Part of Blood & lymphatic clinical trials.
This trial tests a stem cell transplant using a milder conditioning regimen and a drug called post-transplant cyclophosphamide to treat severe aplastic anemia and other acquired bone marrow failure conditions. The goal is to help patients achieve a functioning donor bone marrow with fewer side effects.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have severe aplastic anemia or another acquired bone marrow failure condition (like PNH, pure red cell aplasia, or amegakaryocytic thrombocytopenia).
- Your blood counts are very low (e.g., low platelets, low neutrophils, or low reticulocytes) and you may need transfusions.
- You have a donor available for a stem cell transplant and are willing to undergo a reduced-intensity transplant.
- You do not have an uncontrolled infection, severe liver scarring, or a known inherited bone marrow failure disorder.
- You are not pregnant and agree to use birth control if needed.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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