Stem cell transplant for chronic granulomatous disease
Treatments studied
Part of Blood & lymphatic, Genetic & congenital, Immune system & allergy clinical trials.
This study tests a stem cell transplant using a special conditioning regimen to treat chronic granulomatous disease (CGD), a condition that causes repeated infections and inflammation. The transplant aims to replace faulty immune cells with healthy ones from a donor, potentially reducing infections and improving quality of life.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a confirmed diagnosis of chronic granulomatous disease (CGD).
- You must have had serious complications from CGD, such as ongoing inflammation or a serious infection, or have very low oxidase production (a measure of immune function).
- You must be between 4 and 65 years old.
- You must have a suitable donor, either a matched family member or a matched unrelated donor (with up to one mismatch).
- You must be able to stay within 1 hour of the NIH for the first 3 months after transplant and have a caregiver to help you.
- You must not be pregnant or breastfeeding, and you must agree to use contraception if applicable.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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