Bempedoic acid to lower cholesterol and inflammation in HIV
Treatments studied
Part of Heart & circulation, Hormones & metabolism, Immune system & allergy, Infections clinical trials.
This Phase 2 trial studies whether bempedoic acid can lower cholesterol and inflammation in people with HIV who are already on effective HIV medications. It may help reduce signs of artery inflammation that can contribute to heart and stroke risk.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a documented HIV infection and have been on the same HIV medicines continuously with an undetectable viral load for at least 12 weeks.
- Your CD4 count (a key immune cell measure) is at least 200.
- You are age 40 or older, and your LDL (“bad”) cholesterol is at least 50 mg/dL.
- You have either known cardiovascular disease (like prior heart attack or stroke) or at least one major risk factor (such as diabetes, smoking, high blood pressure, abnormal cholesterol, elevated inflammation marker hsCRP, or strong family history).
- Imaging shows enough “artery inflammation” at baseline (TBR must be above 1.6).
- If you can become pregnant: you must be post-menopausal/without periods for over 12 months, or use two reliable contraception methods (one hormonal and one barrier) and have a negative pregnancy test before starting; if you’re male, you must use contraception.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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