Diphenhydramine to help sleep in autistic children
Treatments studied
Part of Mental health clinical trials.
This Phase 2 study tests whether diphenhydramine improves sleep in children with autism who have significant sleep problems. It requires sleep monitoring (watch data and sleep testing) and checking for side effects to see if the treatment is safe and helpful.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your child is 8 to 17 years old and lives with a caregiver who can bring them to visits
- Your child has a confirmed autism diagnosis (based on specialist evaluation and specific autism assessments)
- Your child has sleep problems, with a screening score of 41 or higher on a sleep questionnaire
- Your child can do sleep tracking, including sleep study testing and wearing an activity watch
- Your child’s medications are stable: most must be unchanged for at least 2 weeks (and Prozac for 4 weeks)
- You can follow the plan for the whole study, including no major changes in behavioral/medical supports during the trial
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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