Testing sacubitril/valsartan vs ramipril for heart failure
Treatments studied
Part of Heart & circulation clinical trials.
This trial compares two blood-pressure and heart-failure medicines: sacubitril/valsartan versus ramipril, to see which improves heart pumping and heart structure over time. It’s aimed at people with ischemic (blocked-artery) heart failure with mid-range ejection fraction and ongoing symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be an adult (18 or older) and sign consent before any study steps
- Have heart failure symptoms (NYHA class II to IV) caused by heart disease from blocked arteries
- Your heart pumping strength (ejection fraction) should be between 40% and 49%
- Have evidence of strain/heart failure on a blood test (NT-proBNP at or above 125 pg/mL)
- Currently be on the best usual heart-failure medicines like an ACE inhibitor or ARB plus a beta-blocker, unless a doctor says you can’t
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests sacubitril/valsartan to help prevent heart weakness (cardiotoxicity) caused by breast cancer treatments like anthracyclines and/or anti-HER2 drugs. If you qualify, you may be offered this heart-protection medicine while your cancer is treated.
This trial tests whether a combination of two blood pressure drugs (sacubitril/valsartan) is better than one drug alone (valsartan) at improving heart function in people with high blood pressure. It may help reduce strain on the heart's upper chambers.
This study tests whether a medication called sacubitril/valsartan can improve the heart's ability to relax and fill with blood (diastolic function) in people with heart failure with reduced ejection fraction. It may help improve your heart function and overall well-being.
This trial tests a drug called sacubitril/valsartan to see if it helps people who have both a prosthetic heart valve and heart failure with a weak heart pump. The goal is to improve heart function and symptoms.
This trial tests a medicine called sacubitril-valsartan for people in rural Tanzania with heart failure and reduced pumping strength. It aims to see if switching to this drug can improve symptoms and outcomes.
This Phase 3 study tests whether S086 tablets can improve treatment for people with chronic heart failure where the heart pumps weakly. You may be eligible if your heart failure symptoms are moderate to severe and your condition is stable on current medicines, but not if you’ve recently had certain heart events or can’t take related blood-pressure/heart drugs.
Hear when a new Heart Failure With Moderately Reduced Ejection Fraction trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.