Clin2
NCT05540834Possibly a fitRecruiting

Testing blood-clot guidance for ICU patients with severe lung failure

Acute Respiratory FailureHypercoagulabilityFibrinolysis Shutdown

Treatments studied

Part of Blood & lymphatic clinical trials.

This Phase 2 trial tests whether using a blood test that shows clotting strength and “clot breakdown time” can help guide treatment for people in the ICU with acute respiratory failure from infection. If you qualify, the team will use these blood results to decide on clot-related therapy and compare outcomes to standard care.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
70 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • Be 18 to 75 years old
  • Be admitted to the ICU for sudden, severe breathing failure from an infection in the lungs or elsewhere
  • Have low oxygen levels despite support (oxygen level ratio fits the study’s cutoff) and use PEEP 5 or higher
  • Your blood test results must show a stronger tendency to clot plus enough time for clot breakdown (specific lab cutoffs)
  • You must be able to have the study blood tests and receive active ICU treatment; the team believes you can survive at least the next day

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06680180Recruiting
Blood Clot Breakdown in Severe Infection and Injury

This trial studies how well the body's natural clot-busting system works in people with serious infections or major injuries. It may help doctors find better ways to treat these conditions.

Canberra, Australian Capital Territory
NCT06357403Recruiting
Predicting blood clots in ICU patients with a blood test

This study looks at whether a blood test measuring a substance called anti-factor Xa activity can help predict dangerous blood clots in critically ill patients. If you join, researchers will follow you to see if the test results can prevent clots.

Graz, Styria
NCT06487052Recruiting
Catheter-based clot-dissolving drug for intermediate-high risk pulmonary embolism

This trial tests whether a standard procedure using a catheter to deliver clot-dissolving medicine directly into the lung artery works well for people with a serious but not immediately life-threatening blood clot in the lungs (pulmonary embolism). It aims to improve heart function and reduce long-term complications.

Saint Petersburg
NCT06143969Recruiting
Ultrasound-guided clot-dissolving treatment for intermediate-high risk pulmonary embolism

This trial tests a treatment that uses ultrasound to guide a thin tube (catheter) to deliver clot-busting medicine directly into the blood clot in your lung. It may be an option for people whose clot is serious but not yet causing shock, and who have symptoms that started within the last two weeks.

Milan, Italia
NCT06768138Recruiting· Phase 3
Giving clot-busting medicine directly into the brain after successful blood flow restoration

This trial tests whether a clot-busting drug given directly into the brain artery can improve recovery after a major stroke caused by a blockage in the front part of the brain. The study is for people whose blood flow has already been successfully restored with standard treatments.

Nancy
NCT07389460Recruiting· Phase 3
Study of a clot-busting drug before thrombectomy for stroke

This trial tests giving a clot-dissolving medicine (rhPro-UK) through a vein before a procedure to remove a large blood clot in the brain. It is for people who had a stroke 4.5 to 24 hours ago and are already scheduled for clot removal. The goal is to see if the medicine helps improve blood flow and outcomes.

Lanzhou, Gansu

Hear when a new Acute Respiratory Failure trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.