Clinical trials
Acute Respiratory Failure clinical trials
Below are recruiting acute respiratory failure clinical trials, each written for real people, not researchers. We’re tracking 179 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06501118Recruiting
Oxygen levels in ICU patients on breathing machines
This study tests whether giving a little more oxygen to ICU patients on breathing machines leads to better recovery. It compares usual oxygen levels to a more liberal target to see which is safer and more effective.
Aurora, ColoradoAges 18 years+ - NCT06675045Recruiting
High flow oxygen therapy and breathing patterns
This study looks at how breathing changes in patients with low blood oxygen levels who are treated with high-flow oxygen through a mask. It aims to understand which patients might need a breathing tube.
MarseilleAges 18 years+ - NCT06881927RecruitingPhase 4
Reducing anti-rejection meds in ICU for kidney transplant patients
This study tests whether quickly reducing your anti-rejection medicines during a life-threatening ICU stay can help your kidneys recover and improve your overall outcome. It is for kidney transplant recipients with septic shock or severe breathing failure.
StrasbourgAges 18 years+ - NCT07189078Recruiting
Comparing intubation methods for patients with low blood oxygen
This study tests two different ways to place a breathing tube in patients who are in intensive care with very low oxygen levels and need help breathing. The goal is to find which method is safer and works better for patients like you.
AngersAges 18 years+ - NCT06967441Recruiting
Respiratory viruses and acute heart failure study
This trial looks at whether a respiratory virus might be triggering your heart failure. It will test your nasal swab for viruses to help doctors understand and treat your condition better.
Seongnam-si, Gyeonggi-doAges 19 years+ - NCT06989385Recruiting
Studying breathing support failure in respiratory failure
This study looks at why some patients with acute respiratory failure do not improve with non-invasive breathing support like high-flow nasal oxygen (HFNO) or non-invasive ventilation (NIV). It aims to find patterns that might predict when these treatments are not enough.
ModenaAges 18 years+ - NCT05670093Recruiting
Testing pressure support to ease breathing muscle work
This trial looks at a breathing-support setting that may reduce the effort of your breathing muscles while you’re coming off a ventilator. It’s meant for people who have been on a breathing machine for more than 24 hours during the “weaning” phase.
SolnaAges 18 years+ - NCT04912960Recruiting
PEEP breathing support for adults with acute lung failure
This trial studies whether a specific breathing setting called PEEP can help adults whose lungs are failing and who need a breathing machine. Doctors will compare outcomes in patients who fit this critical illness pattern and are safe for the required positioning and ventilator settings.
Las Palmas de Gran Canaria, Las PalmasAges 18 years+ - NCT05347563Recruiting
Using a chest sensor to improve ventilation in sick children
This trial tests whether a special chest sensor (called electrical impedance tomography, or EIT) can help doctors distribute breathing support more effectively in children with sudden breathing failure. It may help optimize ventilation while the child is being monitored in intensive care or during anesthesia.
Bron, RhoneAges birth–18 years - NCT07638293Recruiting
High-Flow Oxygen Therapy Weaning Protocols for Respiratory Failure
This trial compares two different approaches to gradually reducing high-flow nasal oxygen therapy (a breathing support treatment delivered through your nose) in patients with acute respiratory failure. The goal is to find the best way to safely stop this treatment and transition you to breathing on your own.
Milan, LombardyAges 18 years+ - NCT07686315Recruiting
Safer breathing with advanced monitoring on a ventilator
This trial is testing a new way to monitor your breathing while you are on a ventilator, to make it safer. It is for people who need a ventilator for reasons other than lung failure, like after a coma, injury, or severe infection.
Milan, LombardyAges 18 years+ - NCT06213168Recruiting
CPAP plus high-flow oxygen vs oxygen alone for breathing failure
This study tests whether adding a breathing machine (CPAP) to high-flow oxygen can help people with sudden breathing failure more than high-flow oxygen alone. It is for adults recently admitted to the ICU with low oxygen levels.
AmiensAges 18 years+ - NCT07423338Recruiting
Monitoring breathing muscles in respiratory failure patients
This study tests a new way to monitor breathing muscles in patients who need extra oxygen or breathing support, like a mask or high-flow oxygen. It may help doctors better understand how to treat respiratory failure.
LondonAges 18 years+ - NCT07379242Recruiting
Lung recruitment test for breathing failure patients on a ventilator
This trial uses a special imaging technique (electrical impedance tomography) to find the best ventilator settings for patients with acute breathing failure. It may help doctors tailor treatment to improve lung function.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07279831Recruiting
Brain-lung interaction study in acute respiratory failure
This trial looks at how the lung and brain communicate during serious breathing problems. If you are in the ICU with a new breathing issue and need high-flow oxygen therapy, researchers want to study your brain and lung activity together.
ParisAges 18 years+ - NCT07265882Recruiting
Bedside test for breathing tube patients
This trial uses a simple bedside test to evaluate patients who are on a breathing machine and not breathing on their own. It may help doctors better understand and manage acute respiratory failure.
Pavia, PaviaAges 18–90 - NCT03826797Recruiting
Testing breathing pressure signals in serious lung breathing failure
This study looks at how pressure readings from a breathing tube compare with whether non-invasive breathing support fails in people with sudden, severe low oxygen levels. It may help improve how clinicians spot who will need stronger breathing treatment sooner.
ModenaAges 18 years+ - NCT06479421Recruiting
AI study to personalize care for sudden breathing failure
This study is developing an artificial intelligence (AI) tool to help doctors choose the best treatment for people with sudden breathing failure. It compares patients who need breathing support to those who do not, to find patterns that improve care.
Seoul, GangnamAges 18 years+ - NCT06319274RecruitingPhase 2
Prostacyclin for lung infection patients on a ventilator
This study tests a medicine called prostacyclin (given through a vein) to see if it helps people on a breathing machine with a lung infection. The goal is to reduce inflammation and improve recovery.
CopenhagenAges 18 years+ - NCT06703073RecruitingPhase 2
Testing new treatments for acute respiratory distress syndrome (ARDS)
This trial is testing new treatments for people with ARDS, a serious lung condition. The goal is to find therapies that help patients breathe better and recover faster. If you or a loved one has ARDS, this study may offer access to experimental treatments.
Birmingham, AlabamaAges 18 years+ - NCT06701656RecruitingPhase 2
Testing bevacizumab for breathing problems from ARDS
This trial tests if bevacizumab can help people with ARDS (a serious lung condition) breathe better. It is for patients with mild, moderate, or severe ARDS who are already in the hospital.
Birmingham, AlabamaAges 18 years+ - NCT06513949RecruitingPhase 2
Testing IC14 for ARDS on a ventilator
This trial tests a new treatment called IC14 for people in the hospital on a breathing machine for ARDS (a severe lung injury). The study aims to see if IC14, which blocks a protein involved in inflammation, can help the lungs heal faster.
Seattle, WashingtonAges 18 years+ - NCT03033251Recruiting
Compare high-flow oxygen to noninvasive ventilation for COPD flare-ups
This study compares two breathing support options for people hospitalized with a COPD flare-up and high carbon dioxide levels in the blood. It aims to see which option works better and is safer for breathing and recovery.
Toronto, OntarioAges 40 years+ - NCT03642002Recruiting
Music therapy for adults on breathing machines in the ICU
This trial tests whether music therapy can improve comfort and recovery for adults who need a breathing machine (mechanical ventilation) in the ICU for at least 48 hours. It may help with stress, mood, and other ICU-related symptoms while you are in critical care.
New York, New YorkAges 18 years+
Hear when a new Acute Respiratory Failure trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Acute Respiratory Failure trials by city
Studies with a site in or near these metro areas.
Acute Respiratory Failure trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for acute respiratory failure?
- Yes. Clin2 currently lists 179 recruiting acute respiratory failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a acute respiratory failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a acute respiratory failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.