Clinical trials
Acute Respiratory Failure clinical trials
Below are recruiting acute respiratory failure clinical trials, each written for real people, not researchers. We’re tracking 172 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07463885Recruiting
Breathing on your own vs machine breathing for low oxygen
This study tests whether letting patients with serious breathing problems breathe on their own (with a breathing tube still in place) is better than the usual way of using the ventilator to do all the breathing. It may lead to faster recovery and less harm.
Oslo, OsloAges 18 years+ - NCT03826797Recruiting
Testing breathing pressure signals in serious lung breathing failure
This study looks at how pressure readings from a breathing tube compare with whether non-invasive breathing support fails in people with sudden, severe low oxygen levels. It may help improve how clinicians spot who will need stronger breathing treatment sooner.
ModenaAges 18 years+ - NCT03793257Recruiting
ECMO patient registry for adults in Australia and New Zealand
This is a research registry for adults who need a breathing and/or heart support machine called ECMO while in the hospital. It collects information to better understand who receives ECMO and how patients do over time.
Canberra, Australian Capital TerritoryAges 18 years+ - NCT04158479Recruiting
Registry for people on ECMO life support
This registry collects information about people who are placed on ECMO, a heart-lung machine used to support breathing and/or circulation. It may help doctors better understand who benefits and how to manage ECMO in the future.
Beijing, Beijing MunicipalityAges Any age - NCT05540834RecruitingPhase 2
Testing blood-clot guidance for ICU patients with severe lung failure
This Phase 2 trial tests whether using a blood test that shows clotting strength and “clot breakdown time” can help guide treatment for people in the ICU with acute respiratory failure from infection. If you qualify, the team will use these blood results to decide on clot-related therapy and compare outcomes to standard care.
Liverpool, New South WalesAges 18–75 - NCT07845305Enrolling by invitation
Breathing tube placement with sedation only to preserve breathing
This study tests whether giving only sedation (not a paralytic drug) during emergency breathing tube placement can help you keep breathing on your own. It aims to see if this approach is safer and helps recovery.
Nashville, TennesseeAges 18 years+ - NCT07814118Enrolling by invitation
Understanding how your body works during routine care
This study looks at how different body systems work together in people with various conditions and healthy volunteers. It uses routine medical tests and data to understand health better, which can help improve future care.
New York, New YorkAges 18 years+ - NCT07686315Recruiting
Safer breathing with advanced monitoring on a ventilator
This trial is testing a new way to monitor your breathing while you are on a ventilator, to make it safer. It is for people who need a ventilator for reasons other than lung failure, like after a coma, injury, or severe infection.
Milan, LombardyAges 18 years+ - NCT07673250Enrolling by invitation
Personalized breathing settings for ECMO patients
This study tests whether personalized breathing machine settings can improve outcomes for people on ECMO (a heart-lung support machine). It is designed for patients who have had or are waiting for a lung or heart transplant.
La Jolla, CaliforniaAges 18 years+ - NCT07638293Recruiting
High-Flow Oxygen Therapy Weaning Protocols for Respiratory Failure
This trial compares two different approaches to gradually reducing high-flow nasal oxygen therapy (a breathing support treatment delivered through your nose) in patients with acute respiratory failure. The goal is to find the best way to safely stop this treatment and transition you to breathing on your own.
Milan, LombardyAges 18 years+ - NCT07607080Recruiting
Predicting Treatment Success for High-Flow Oxygen Support
This study helps doctors predict which patients receiving high-flow oxygen through a nasal tube will need additional breathing support. Researchers use blood tests and clinical information to identify who might need a ventilator, allowing earlier interventions if needed.
Barcelona, CataloniaAges 18 years+ - NCT07558265Recruiting
Comparing breathing support methods in the emergency department
This study tests two common ways to help people who are having trouble breathing in the emergency room: a face mask that pushes air into the lungs (non-invasive positive pressure ventilation) or high-flow oxygen through small tubes in the nose (high-flow nasal oxygen). The goal is to find which method works better to avoid needing a breathing tube.
Tucson, ArizonaAges 18 years+ - NCT07542366Recruiting
Testing a new lung imaging method in ICU patients
This study tests whether a special imaging technique called EIT (electrical impedance tomography) combined with a safe contrast injection can measure blood flow in the lungs of patients on breathing machines. If it works, it could help doctors better manage critically ill patients.
Wuhu, AnhuiAges 18 years+ - NCT05681962Recruiting
Improving breathing support during flexible bronchoscopy
This trial studies how to give oxygen and breathing support during a flexible bronchoscopy (a camera test through the airways). It may help make the procedure safer and more comfortable by refining the way oxygen is managed during the test.
CatanzaroAges 18 years+ - NCT07521254Recruiting
High-flow oxygen and breathing support for acute respiratory failure
This trial tests whether high-flow oxygen delivered through the nose, combined with non-invasive breathing support (a mask that helps you breathe without a tube down your throat), can help patients with sudden severe breathing problems. The goal is to improve oxygen levels and avoid the need for a breathing tube.
Minya, Minya GovernorateAges 18 years+ - NCT06694311Recruiting
Testing CPAP and high-flow oxygen for ARDS
This study tests two types of breathing support—CPAP (a mask that pushes air into your lungs) and high-flow nasal oxygen (a special tube in your nose)—to see which works better for people with ARDS, a serious lung condition. It may help you breathe more easily without needing a breathing tube.
Barcelona, BarcelonaAges 18–80 - NCT06374589Recruiting
Closing the loop on oxygen use during high flow therapy
This trial tests a system that automatically adjusts oxygen levels for patients receiving high flow oxygen therapy. The goal is to see if it can keep oxygen levels in a safe range better than usual care.
IstanbulAges 18 years+ - NCT07450846Recruiting
Heart-lung interaction in severe breathing problems
This study looks at how the heart and lungs interact in patients with acute respiratory distress syndrome (a severe lung condition) who are on a breathing machine. Researchers will use ultrasound to check heart function at different times during treatment.
Le Kremlin-BicêtreAges 18 years+ - NCT07423338Recruiting
Monitoring breathing muscles in respiratory failure patients
This study tests a new way to monitor breathing muscles in patients who need extra oxygen or breathing support, like a mask or high-flow oxygen. It may help doctors better understand how to treat respiratory failure.
LondonAges 18 years+ - NCT07379242Recruiting
Lung recruitment test for breathing failure patients on a ventilator
This trial uses a special imaging technique (electrical impedance tomography) to find the best ventilator settings for patients with acute breathing failure. It may help doctors tailor treatment to improve lung function.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06795971Recruiting
Comparing oxygen methods for hypoxemic respiratory failure
This trial compares three ways of giving extra oxygen to people with low blood oxygen levels: a face mask with continuous pressure, a noninvasive ventilator, or high-flow oxygen through the nose. The goal is to see which method helps people avoid needing a breathing tube.
Nanjing, JiangsuAges 18 years+ - NCT06774534Recruiting
SerpinB3 protein in acute respiratory distress
This study looks at a protein called SerpinB3 and its role in severe lung inflammation (ARDS). It may help doctors understand how ARDS develops and find new ways to treat it.
Padova, PDAges 18 years+ - NCT07334379RecruitingPhase 2
Personalized treatment for hospitalized patients with breathing problems
This study tests a personalized approach for hospitalized patients with acute breathing problems. It uses a blood test to guide whether they receive a common steroid or a targeted medication (tocilizumab) to reduce inflammation, with the goal of improving recovery.
Toronto, OntarioAges 18 years+ - NCT05731024Recruiting
Closed-loop breathing control vs standard care for kids in ICU
This study compares a computerized “closed-loop” system that helps match breathing support to a child’s needs versus usual (standard) breathing control. It’s for critically ill children on a breathing machine, aiming to improve synchronization between the child and the ventilator.
AydinAges 1 month–18 years
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Acute Respiratory Failure trials by city
Studies with a site in or near these metro areas.
Acute Respiratory Failure trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for acute respiratory failure?
- Yes. Clin2 currently lists 172 recruiting acute respiratory failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a acute respiratory failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a acute respiratory failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.