Study of defibrillator implants for non-ischemic weak heart
Part of Heart & circulation clinical trials.
This study looks at whether implantable defibrillators can reduce dangerous heart rhythms in people with non-ischemic cardiomyopathy (heart weakness not caused by blocked heart arteries), a heart scar, and very low pumping strength despite best treatment. It compares different approaches to choosing which patients should receive these devices.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your heart problem is non-ischemic cardiomyopathy, confirmed by a special heart MRI with contrast
- Your heart MRI shows a left-ventricle scar (people without scar can join a registry, but not this device comparison)
- Your heart pumping is very weak (left ventricular ejection fraction 35% or less) after at least 3 months of best medical treatment
- You feel at least mildly-to-moderately limited by heart failure symptoms (NYHA class I to III) and not class IV
- You have never had an implantable device like an ICD, CRT, or pacemaker already
- You can and are willing to give informed consent
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests if doing a special heart procedure (catheter ablation) at the same time as implanting a defibrillator (ICD) can prevent dangerous heart rhythms better than the ICD alone. It is for people with a very weak heart pump due to blocked arteries who are getting a first-time ICD.
This study looks at placing an ICD, a device that can stop dangerous heart rhythms, to help prevent sudden cardiac death. It is for people over 70 with specific heart function and heart failure symptoms.
This study is testing a new type of implantable cardioverter-defibrillator (ICD) or cardiac resynchronization therapy defibrillator (CRT-D) called the CorSky Family. The goal is to see how well it works for people who need a device to help their heart pump properly and prevent dangerous rhythms.
This trial evaluates a noninvasive way to assess who should get Cardiac Resynchronization Therapy (CRT), and to check results after implantation. If you fit the heart rhythm and heart pump criteria, the approach may help confirm whether CRT is appropriate for you.
This study looks at how a pacemaker-like device (cardiac resynchronization therapy) affects heart function in people with heart failure and reduced ejection fraction. It may help you understand if this treatment is right for you and could improve your heart health.
This study compares modern heart failure medications and implantable cardioverter-defibrillators (ICDs) to reduce the risk of sudden cardiac death in people with a specific type of heart muscle disease (non-ischemic cardiomyopathy) that is not caused by blocked arteries. It may help guide treatment decisions for those with a weakened heart and certain scarring on heart MRI.
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