Clinical trials
Heart failure clinical trials
A condition where the heart can’t pump blood as well as it should. We’re tracking 946 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06280820Enrolling by invitation
A study of heart failure patterns (MAP-HEART)
This study looks at different types of heart failure to understand them better. You may join if you have active heart failure (with symptoms like shortness of breath or swelling) and are willing to participate in research activities.
Baltimore, MarylandAges 18–100 - NCT02998788Recruiting
Heart failure risk monitoring for hospitalized adults
This trial studies how to better assess and manage risk in people hospitalized with heart failure or related serious heart problems. It may help by improving how clinicians monitor your condition over time and decide next steps.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT03772275Recruiting
Tests new blood markers in chronic heart failure patients
This study looks at whether certain new blood tests (biomarkers) can help doctors learn more about chronic heart failure. You might be asked for blood samples and health information, and the results could improve how heart failure is understood in the future.
Tanta, ElgharbiaAges 18–75 - NCT04062500Recruiting
Heart failure patient follow-up study to track health and deaths
This study follows people with heart failure over time to record outcomes like illness course and death, and to understand how treatments affect results. If you have heart failure and can join regular check-ins, your information may help improve future care.
Shanghai, Shanghai MunicipalityAges 18–90 - NCT04305717Recruiting
Check fluid levels with a special sensor in hospitalized heart failure
This study uses a noninvasive device (ReDS) to estimate fluid buildup in people hospitalized with acute heart failure. It may help doctors monitor fluid status and guide care more accurately during a hospital stay.
New York, New YorkAges 18 years+ - NCT02814942Recruiting
Testing CRT in people with weak hearts and wide ECG signals
This study looks at whether a device called CRT (Cardiac Resynchronization Therapy) can help people with heart failure who have a weak heart pumping strength and a “wide” electrical signal pattern on an ECG. It may help some people feel better and improve heart function, especially if they are not already on the best standard medicines.
SingaporeAges 18 years+ - NCT03951311Recruiting
Diet and lifestyle study for people with weaker heart pumping
This study looks at how metabolic changes, diet, and lifestyle patterns affect heart failure. It may help find ways to improve symptoms and health by targeting diet and daily habits.
Shanghai, Shanghai MunicipalityAges 14–90 - NCT05250349Recruiting
Ultrasound brain blood flow and thinking in stable heart failure
This trial studies whether a noninvasive ultrasound test of blood flow in the brain, along with memory and thinking questionnaires, can help explain thinking changes in people with stable heart failure. It may help researchers better understand why some people develop cognitive (thinking) difficulties as heart failure progresses.
Krakow, MPAges 18 years+ - NCT05508256RecruitingPhase 4
Ablation for atrial fibrillation in heart failure with preserved function
This trial tests whether a catheter procedure that treats atrial fibrillation works better than standard care for people with heart failure with preserved ejection fraction. It aims to improve heart rhythm symptoms and overall outcomes compared with conventional treatment.
BerlinAges 18 years+ - NCT04741711Recruiting
At-home ultrasound to help manage heart failure
This study tests whether using lung ultrasound at regular visits can help guide care for people with heart failure. It may help doctors spot worsening fluid problems earlier, before symptoms become severe.
BesançonAges 18 years+ - NCT06061549RecruitingPhase 1
Gene therapy for stiff heart failure (preserved EF)
This trial tests a one-time gene therapy for people with heart failure who still have normal pumping strength (preserved ejection fraction). It aims to improve how heart cells handle calcium, which may help the heart relax better and ease symptoms.
Durham, North CarolinaAges 50 years+ - NCT05063955Recruiting
Study muscle changes in people with heart failure
This study looks at the reasons for age-related muscle loss (sarcopenia) in people with heart failure. It may help researchers understand what is causing muscle weakness and how it could be treated in the future.
Aarhus NAges 18–90 - NCT07862933Recruiting
AI chat support for older adults with heart failure
This study tests an AI-powered chat system that offers social support to older adults with chronic heart failure. It may help you feel more supported and manage your condition better.
New Taipei City, New Taipei CityAges 60 years+ - NCT06278844Recruiting
Pacing method to improve exercise in heart failure
This study tests a new way to pace the heart in people with heart failure who need a pacemaker. It aims to see if this pacing method helps them exercise more easily.
Edegem, AntwerpAges 18 years+ - NCT05746923Recruiting
Heart failure hospital registry for adults in Krakow area
This registry collects information from adults who were recently hospitalized for acute heart failure. It helps researchers better understand who is affected and how care is delivered after hospitalization.
KrakowAges 18 years+ - NCT05859048Recruiting
Care plan to help high-risk people spot heart failure early
This trial tests a multidisciplinary care approach aimed at helping people with high risk for heart failure get diagnosed earlier. It may help you catch heart failure sooner if it starts, so treatment can begin earlier.
Vancouver, British ColumbiaAges 40 years+ - NCT04703842RecruitingPhase 1/Phase 2
Study drug effect on heart muscle calcium in advanced heart failure
This trial tests a treatment intended to improve how heart muscle cells handle calcium, which may help heart failure symptoms and heart function. It is mainly for people with advanced heart failure and a low pumping strength of the heart.
San Diego, CaliforniaAges 18–80 - NCT05632432Recruiting
Heart tissue grafts to help the heart after surgery
This trial tests whether transplanting tiny heart “micrografts” from the left heart chamber area can improve heart function after cardiac surgery. It is meant for people with weakened heart pumping and heart failure symptoms despite medicine.
Helsinki, UusimaaAges 18–75 - NCT06286423RecruitingPhase 4
Colchicine for acute heart failure with low pumping strength
This trial tests if the anti-inflammatory drug colchicine can help people hospitalized with acute heart failure and a weak heart pump. It may benefit those with elevated inflammation markers.
Charlottesville, VirginiaAges 18 years+ - NCT03323216Recruiting
Testing heart-related blood markers in people with diabetes and heart failure
This study looks for blood markers that may help explain or predict heart problems in people who have type 2 diabetes and heart failure. To join, you may also need to be having a planned heart procedure where doctors can collect study information.
Aachen, North Rhine-WestphaliaAges 18 years+ - NCT06444321Recruiting
Integrated care for frail patients with heart failure
This trial tests a special care program for people with both frailty (being weak or vulnerable) and heart failure (when the heart doesn't pump well). The program brings together different types of support to help you manage your health better after a hospital stay.
Drammen, AkershusAges 18 years+ - NCT07820410RecruitingPhase 2/Phase 3
Atrial shunt for heart failure with reduced pumping function
This study tests a small device that creates a tiny opening inside the heart to help lower pressure and improve symptoms in people with heart failure. The procedure is minimally invasive and aims to reduce hospitalizations and improve quality of life.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07817589Recruiting
Adding yoga to exercise rehab for heart failure
This study tests whether adding yoga to a hospital-based cardiac rehabilitation program can improve the health and well-being of people with heart failure. It might help you feel better and manage your condition more effectively.
Dharwad, KarnatakaAges 18 years+ - NCT07814612Recruiting
Guided pacing for heart failure with left bundle branch block
This study tests a new way to place a pacemaker lead inside the heart to help it beat more effectively, aiming to improve heart function and symptoms in people with heart failure and a specific electrical problem (left bundle branch block). If you meet the criteria, this could be an option to discuss with your heart doctor.
Nanchang, JiangxiAges 18–80
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Heart failure trials by city
Studies with a site in or near these metro areas.
Heart failure trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for heart failure?
- Yes. Clin2 currently lists 946 recruiting heart failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.