Studying an MRI contrast method in mitochondrial muscle disease
Part of Bones, joints & muscles, Brain & nervous system, Hormones & metabolism clinical trials.
This Phase 1 study tests a special MRI approach (using a contrast agent) to better measure changes in muscles in people with mitochondrial diseases. It also includes some healthy volunteers and other critically ill patients to compare results and check safety.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Ages 10 to 60 years (Aim 1) or 10 to 23 years (Aim 2) and at least 135 cm tall for Aim 1
- You must be able to complete the required exercise testing (Aim 1) or be non-ambulatory in the PICU (Aim 2)
- You must be willing and able to follow all study procedures and instructions
- For people with mitochondrial disease: you need a genetic confirmation of mitochondrial myopathy (for the PMD Aim 1 group)
- You must be able to lie flat in an MRI scanner for up to 45 minutes and complete ankle exercise during the MRI
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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