Study drug for relapsed or hard-to-treat B-cell leukemia
Treatments studied
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This early study tests MK-1045 in people with precursor B-cell acute lymphoblastic leukemia (B-ALL) that has come back or did not respond to earlier treatment. It may help shrink leukemia and improve remission in patients with limited options.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are age 18 or older, or you are between 2 and 17 years old
- You have precursor B-cell acute lymphoblastic leukemia (B-ALL), and at least 5% leukemia cells are found in bone marrow
- Your leukemia is “refractory” (did not respond) or has relapsed (come back) based on specific past-treatment timelines
- If your B-ALL is Ph-positive, you have had at least 2 prior targeted tablet medicines, or you have a specific mutation called T315I
- You have not had anti-CD19 treatment in the last 3 months and have not had CAR-T in the last 3 months
- You have no major problems that would raise safety risk, such as serious brain/spinal cord leukemia involvement, certain infections, major heart/stroke disease, or uncontrolled autoimmune disease
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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