Clin2
NCT05602363Possibly a fitRecruiting

Docirbrutinib for CLL or lymphoma after prior treatments

B-cell MalignancyChronic Lymphocytic LeukemiaSmall Lymphocytic LymphomaWaldenstrom MacroglobulinemiaMantle Cell LymphomaMarginal Zone LymphomaFollicular LymphomaNon-Hodgkin Lymphoma

Part of Blood & lymphatic, Cancer, Heart & circulation, Immune system & allergy clinical trials.

This Phase 1 study tests docirbrutinib, a targeted pill treatment, in people with CLL/SLL or certain other B-cell lymphomas that have come back or didn’t respond to earlier therapy. The goal is to see whether it’s safe and whether it can control the disease after standard treatments have failed.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1
Enrollment
120 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are at least 18 years old and can sign consent to join the study.
  • You have a confirmed B-cell cancer such as CLL/SLL, WM, MCL, MZL, or FL.
  • Your cancer has not responded to (or you couldn’t tolerate) at least two earlier medicine treatments.
  • Your blood counts, liver, and kidney function must be strong enough for study treatment.
  • You can swallow the study pills and follow all study rules; your body must not require certain supportive treatments like blood transfusions or growth-factor medicines for safety.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT05254743Recruiting· Phase 3
Pirtobrutinib versus ibrutinib for CLL or SLL

This Phase 3 trial compares two oral medicines—pirtobrutinib and ibrutinib—in people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who need treatment. It’s designed to see which drug works better and is easier to take, especially for people with a specific genetic change in the cancer (17p deletion).

Anaheim, California
NCT06588478Recruiting· Phase 2
Study of pirtobrutinib for CLL or SLL

This trial tests a new drug called pirtobrutinib for people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). It is for those whose cancer has come back or not responded to treatment, including a prior BTK inhibitor, and also for those who have never been treated but have a specific genetic change (17p deletion).

Chandler, Arizona
NCT06333262Recruiting· Phase 2
Fixed-duration pirtobrutinib and obinutuzumab for untreated CLL

This trial tests a combination of two drugs, pirtobrutinib (a pill) and obinutuzumab (an infusion), given for a set period of time in people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have not had any previous treatment for their disease. The goal is to see if this combination can control the cancer effectively.

Scarborough, Maine
NCT06466122Recruiting· Phase 2
Pirtobrutinib plus Venetoclax for resistant CLL or SLL

This trial tests two oral targeted drugs—pirtobrutinib and venetoclax—for people with CLL or SLL whose disease has continued to grow despite taking a BTK inhibitor (such as ibrutinib, acalabrutinib, or zanubrutinib). The goal is to see if this combination can control the cancer when a BTK inhibitor alone is no longer working.

Columbus, Ohio
NCT06812715Recruiting· Phase 2
Pirtobrutinib after zanubrutinib for chronic lymphocytic leukemia

This trial tests a new drug, pirtobrutinib, for people with chronic lymphocytic leukemia (CLL) who have already been treated with zanubrutinib (a similar BTK inhibitor). The goal is to see if switching to pirtobrutinib can help control the disease.

Melbourne, Victoria
NCT06973187Recruiting· Phase 3
Comparing two drugs for CLL or SLL after prior treatment

This trial tests a new drug (BGB-16673) against another drug (pirtobrutinib) for people with CLL or SLL that hasn't responded to or has come back after a prior BTK inhibitor treatment. The goal is to see which drug is more effective and safe.

Birmingham, Alabama

Hear when a new Chronic Lymphocytic Leukemia trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.