Vorasidenib plus a peptide vaccine for recurrent low-grade glioma
Part of Brain & nervous system, Cancer clinical trials.
This Phase 1 study tests vorasidenib combined with a personalized tumor-targeting peptide vaccine in adults with a specific type of recurrent brain tumor. It aims to see how safe the combination is and whether it can help slow the tumor’s growth.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- Your first brain tumor biopsy shows IDH1 R132H in the tumor tissue
- You have a recurrent grade 2–3 glioma that is progressing, with more than 2 cm of non-enhancing tumor on an MRI in one direction
- You are only being treated for the first recurrence (not later recurrences)
- Your overall health tests are strong enough: good activity level (Karnofsky ≥ 70) and blood, kidney, and liver levels in safe ranges
- You can have MRI scans, and you will follow the birth control rules (and not be pregnant or breastfeeding)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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