Levetiracetam for newborn seizures: dose-finding study
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial studies how to give levetiracetam to newborn babies with seizures. It’s trying to find a safe dose and see if it can help control seizures in early life.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your baby is term (about 35–44 weeks corrected age) and under 28 days old
- Your baby weighs more than 2200 grams
- The baby has seizures or is thought to be having seizures
- The cause of seizures is not due to correctable blood problems like low blood sugar or low calcium
- A parent/guardian can understand the study and sign consent
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study looks at what causes certain serious seizures that start early in life, and how to treat them. It may help doctors better match treatments to the seizure cause in newborns and young infants.
This trial compares two antiseizure medicines, levetiracetam and phenobarbital, to see which one works better for children whose prolonged seizures (lasting several minutes) do not stop after two doses of a rescue medicine called benzodiazepine.
This study looks back at children who had a prolonged seizure (status epilepticus) and needed a second medicine after the first one didn't work. Doctors want to see how well levetiracetam works compared to phenytoin, so they can choose better treatments for future children.
This study tests treatments for seizures in newborns who have brain injury from lack of oxygen at birth (HIE). It aims to find the best way to control seizures in the first few days of life.
This trial is for adults with uncontrolled epilepsy who have been taking a high dose of Levetiracetam alone for at least a year. It tests whether taking Levetiracetam three times a day works better than the usual schedule.
This trial tests whether giving the seizure medication levetiracetam early can prevent or treat brain problems in people with septic shock. Septic shock is a life-threatening infection that can affect the brain, and this study aims to see if this drug helps protect brain function.
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