Predicting who will benefit from electroconvulsive therapy
Part of Mental health clinical trials.
This study looks for ways to predict how well electroconvulsive therapy (ECT) will work for severe depression. It may help doctors choose the best treatment approach and timing for future patients.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are an inpatient, age 18 to 65
- You have severe unipolar depression (not bipolar depression) diagnosed by their criteria
- Your depression score (HAMD-17) is high enough (23 or more)
- You can understand the study and sign the consent form
- You are on stable antidepressant and antipsychotic medicines for at least 10 days before starting the study
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial studies which electrical “pulse settings” work best during electroconvulsive therapy (ECT) for people with depression. It may help doctors personalize ECT so the treatment is safer and works as well as possible for you.
This trial compares two anesthesia medicines—esketamine plus propofol versus methohexital—for people receiving ECT (electroconvulsive therapy) for severe depression. The goal is to see which anesthesia approach works better and is safer for patients during ECT.
This study looks at “neural biomarkers,” or brain-measurement signals, to see who is most likely to benefit from electroconvulsive therapy (ECT). It focuses on people with certain active psychosis symptoms and specific mental health diagnoses who have tried antipsychotic medication without enough improvement.
This study looks at how ECT affects brain activity and inflammation in older adults with depression. It may help researchers understand why ECT works and improve treatment.
This trial studies better ways to deliver ECT (electroconvulsive therapy) for people with difficult-to-treat depression, including some people with bipolar depression. You may be offered an ECT strategy that’s tailored to your situation, with the goal of improving outcomes and reducing problems.
This study measures changes in your blood and/or body chemistry while you receive electroconvulsive therapy (ECT) for a severe mood episode. The goal is to understand biological signals related to ECT and treatment-resistant depression, which may help improve future care.
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