Tests anesthesia options for ECT in severe depression
Part of Mental health clinical trials.
This trial compares two anesthesia medicines—esketamine plus propofol versus methohexital—for people receiving ECT (electroconvulsive therapy) for severe depression. The goal is to see which anesthesia approach works better and is safer for patients during ECT.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are an inpatient (currently admitted to the hospital).
- You are at least 18 years old.
- Your depression is diagnosed as severe unipolar or bipolar depression, and your depression score is high (HAMD17 24 or higher).
- You can understand the study and sign consent in writing.
- If you can become pregnant, you must have a negative urine pregnancy test before starting.
- You must be cleared by the anesthesia team to safely receive ECT (ASA level 3 or lower), and your antidepressant and antipsychotic meds must be stable for at least 7 days.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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