NM8074 for adults with PNH not yet on complement inhibitors
Treatments studied
Part of Blood & lymphatic clinical trials.
This Phase 2 study tests how well and how safely NM8074 works for adults with paroxysmal nocturnal hemoglobinuria (PNH) who have not recently received a similar “complement inhibitor” medicine. It may help reduce PNH-related blood cell breakdown and anemia, and it will closely monitor side effects.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re age 18 or older and weigh at least 45 kg (about 99 lb).
- Your PNH diagnosis is confirmed by a blood test (flow cytometry) showing PNH clone levels of 10% or more in certain white blood cells.
- You’re having ongoing blood cell breakdown (hemolysis), shown by blood test results.
- Within the last 12 months, you received at least 1 packed red blood cell (pRBC) transfusion, and your hemoglobin is 10.5 g/dL or lower (anemia).
- Your LDH blood level is at least 1.5 times the normal upper limit, and you’ve had meningitis vaccines (MenACWY and MenB) before starting the study medicine.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 2 trial studies NM8074 in adults with paroxysmal nocturnal hemoglobinuria (PNH) whose blood counts and breakdown of red blood cells (hemolysis) are not controlled enough on Soliris. NM8074 is meant to reduce the abnormal immune “complement” activity driving the disease and its symptoms like anemia.
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This study tests a new oral medication called NTQ5082 for people with PNH who have not been treated with a complement inhibitor before. It aims to see if the drug can reduce the breakdown of red blood cells and improve anemia.
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