Study of a new drug for PNH patients with anemia despite current treatment
Treatments studied
Part of Blood & lymphatic clinical trials.
This trial tests a new pill (MY008211A) for people with paroxysmal nocturnal hemoglobinuria (PNH) who still have low red blood cell counts (anemia) even after taking anti-C5 antibody therapy. The goal is to see if this new drug can raise hemoglobin levels and improve energy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older with a body mass index (BMI) of 18 or higher.
- You have been diagnosed with PNH and at least 10% of your red blood cells have the PNH defect.
- You have been on a stable dose of a medicine like eculizumab (anti-C5 antibody) for at least 6 months.
- Your hemoglobin level has been below 10 g/dL (100 g/L) on at least two tests in the past 4 months and still low at screening.
- You must be willing to get vaccines for certain bacteria (meningococcus, pneumococcus, Haemophilus influenzae) before starting the study drug.
- You are not currently taking any other investigational drugs and do not have a history of certain infections or conditions.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial is testing an experimental pill called NTQ5082 for people with PNH who haven't been treated with complement inhibitors before. The goal is to see if it can improve anemia and control PNH symptoms like fatigue and blood clots.
This study tests if the drug XH-S003 is safe and works well over a long period for people with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disease. If you've already taken XH-S003 in a past study and your doctor thinks it helped, you may join to keep getting the treatment.
This trial tests an investigational drug called NM8074 for adults with paroxysmal nocturnal hemoglobinuria (PNH) who have not yet been treated with complement inhibitors. The goal is to see if NM8074 can reduce red blood cell destruction and improve anemia, potentially reducing the need for blood transfusions.
This trial tests a new drug, HS-10542, for people with PNH who are already on a C5 inhibitor like eculizumab or covalizumab but still have low hemoglobin or need transfusions. It aims to see if this additional treatment can improve blood counts and reduce transfusion needs.
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