Levosimendan for brain bleeding from a ruptured aneurysm
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This Phase 2 study tests whether the medicine levosimendan can improve outcomes after a ruptured aneurysm causing bleeding around the brain. It is designed for certain grades of severity in the first hospital days in the surgical intensive care unit.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You are hospitalized in the surgical intensive care unit for aneurysmal subarachnoid hemorrhage (bleeding around the brain from a burst aneurysm).
- Your condition is within specific severity ranges based on WFNS (I to IV) and CT scan grading called mFisher (3 or 4).
- You are not pregnant.
- Your blood pressure and heart rate are not too low or too fast (mean arterial pressure must be 65+ mmHg, and heart rate 120 bpm or less).
- Your kidneys and liver are functioning well enough (kidney filtering not severely reduced; no severe liver disease or signs like liver-encephalopathy).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at how a heart medication called levosimendan works in the body of adults with severe cardiogenic shock. It aims to improve dosing for better outcomes.
This Phase 2 trial tests whether milrinone, a heart-acting medicine, can improve brain blood flow to help prevent delayed brain ischemia after a severe subarachnoid hemorrhage. It may help reduce later brain damage in people who are too ill or sedated for a normal neurologic exam early on.
This study tests whether giving levosimendan early (a heart-strengthening medicine) improves outcomes compared with placebo, on top of standard inotropic support, in people with cardiogenic shock. It mainly looks at whether patients have fewer serious complications or deaths.
This trial studies a spinal fluid (CSF) treatment to help prevent dangerous blood-vessel tightening (vasospasm) after a type of brain bleed caused by an aneurysm. If you qualify, the goal is to reduce complications soon after aneurysm repair.
This study tests if a medicine called tirofiban (which helps prevent blood clots) can improve recovery after a brain aneurysm rupture. It is for people who have had their aneurysm treated with a coil and are at risk of a delayed stroke.
This trial tests whether placing a small drain in the lower back and giving a clot-dissolving medicine (urokinase) into the fluid around the brain can help people recover from a severe bleeding stroke caused by a brain aneurysm. It is for patients who are treated quickly after the bleed.
Hear when a new Sub-arachnoid Haemorrhage trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.