Milrinone to help prevent brain blood-flow complications after aneurysm bleed
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This Phase 2 trial tests whether milrinone, a heart-acting medicine, can improve brain blood flow to help prevent delayed brain ischemia after a severe subarachnoid hemorrhage. It may help reduce later brain damage in people who are too ill or sedated for a normal neurologic exam early on.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be an adult (18 or older) with a severe subarachnoid hemorrhage (bleeding around the brain)
- Be in a deep coma or needing sedation around day 3, so a neurologic exam can’t be done normally (Glasgow Coma Score 8 or less)
- Have no major prior disability before this illness (mRS 0–2)
- Have a family member or trusted person able to sign consent after being fully informed
- Not have serious unstable heart or circulation problems at the time of randomization (for example heart failure needing strong heart-boosting drugs, severe low blood pressure, or septic shock)
- Not have conditions that block safe treatment or testing (for example allergy to milrinone, severe kidney problems, low potassium, or an MRI contraindication)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests if a medicine called tirofiban (which helps prevent blood clots) can improve recovery after a brain aneurysm rupture. It is for people who have had their aneurysm treated with a coil and are at risk of a delayed stroke.
This trial tests whether the drug cilostazol can prevent delayed brain damage in people who have had bleeding from a brain aneurysm. It is for adults who had their aneurysm treated within 72 hours and are in moderate to serious condition.
This trial studies a spinal fluid (CSF) treatment to help prevent dangerous blood-vessel tightening (vasospasm) after a type of brain bleed caused by an aneurysm. If you qualify, the goal is to reduce complications soon after aneurysm repair.
This trial tests whether adding cilostazol to standard nimodipine treatment helps people recover better after a brain aneurysm bursts. Both drugs aim to prevent delayed complications from the bleeding.
This study tests whether nadroparine (a blood-thinning medicine) can improve outcomes after a type of brain bleed called subarachnoid hemorrhage. It focuses on people who have had a brain aneurysm treated with a procedure soon after the bleed.
This trial tests whether placing a small drain in the lower back and giving a clot-dissolving medicine (urokinase) into the fluid around the brain can help people recover from a severe bleeding stroke caused by a brain aneurysm. It is for patients who are treated quickly after the bleed.
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