Clin2
NCT05665244Possibly a fitRecruiting

Cryotherapy for long-lasting cough from nerve signals

Upper-Airway Cough Syndrome

Part of Brain & nervous system, Ear, nose & throat clinical trials.

This trial tests a cold-treatment procedure (cryotherapy) to treat a stubborn cough caused by nerve signaling (not infections or common allergy/acid problems). It may help people whose cough has lasted at least 8 weeks and who have already tried to rule out other causes.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
28 people
Ages
18 years and older
Study type
Observational

Who can take part

  • You are 18 years or older and have been diagnosed with “neurogenic cough.”
  • Your cough has lasted 8 weeks or longer, and doctors have ruled out other causes.
  • Your reflux/heartburn is controlled (not “uncontrolled reflux”).
  • You do NOT have significant nose/upper-airway allergy symptoms (not uncontrolled allergic rhinitis).
  • You are not currently smoking, and you’re willing to join and sign consent for the study.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT04642352Recruiting
Nerve block injections for long-lasting nerve cough

This trial studies an office-based injection to calm a specific nerve in the neck to treat chronic cough that seems to come from nerve irritation (“neurogenic/sensory neuropathic” cough). It may help people whose cough has lasted at least 8 weeks and continues despite standard treatments for common cough causes.

Birmingham, Alabama
NCT07488598Recruiting
Behavioral therapy for hard-to-treat chronic cough

This trial tests a behavioral therapy for people whose chronic cough (lasting more than 8 weeks) hasn't improved with usual treatments like asthma or reflux medicine. You may join if your cough is triggered by things like talking, laughing, cold air, or irritants, and you have throat symptoms like irritation or hoarseness.

Asyut
NCT07671924Recruiting· Phase 2
Testing nalbuphine extended-release for chronic cough

This trial tests whether an extended-release medication called nalbuphine can reduce coughing in people with chronic cough that hasn't improved with other treatments. You may be eligible if you've had a persistent cough for at least a year and have already tried treatments for conditions that could cause it.

Ajax
NCT06960759Recruiting· Phase 2
Cough suppression therapy for chronic cough

This study tests a behavior-based therapy to help you gain control over a persistent cough that hasn't responded to other treatments. You will learn techniques to reduce coughing during a 4-week program.

Aurora, Colorado
NCT05273190Recruiting
Using gentle larynx stimulation to treat chronic unexplained cough

This study tests whether stimulating the larynx (voice box area) can reduce cough that has lasted more than 8 weeks. It may help people whose cough is not clearly explained by infections, lung diseases, or other common causes.

Minneapolis, Minnesota
NCT05110144Recruiting· Phase 2
Testing two doses of two nerve pain medicines for chronic cough

This Phase 2 study tests whether two doses of duloxetine and amitriptyline can reduce symptoms in people with chronic cough that hasn’t responded to usual care. You may join to see if these medicines lessen cough severity over an 8-week blinded treatment period.

Rochester, Minnesota

Hear when a new Upper-Airway Cough Syndrome trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.