Botulinum injections for lower leg exertional muscle pressure pain
Treatments studied
Part of Bones, joints & muscles, Heart & circulation clinical trials.
This trial studies whether injecting botulinum (a medicine that relaxes overactive muscles) into the lower leg can reduce pain and pressure during exercise in people with a confirmed condition called chronic exertional compartment syndrome. It may help by lowering the muscle compartment pressure that builds up after activity.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a confirmed diagnosis of lower leg anterolateral chronic exertional compartment syndrome (CECS) based on pressure tests after exercise
- Your post-exercise muscle pressure is very high right after stopping exercise (over 30 mmHg)
- Your muscle pressure is still high 5 minutes after stopping exercise (over 12 mmHg)
- If you are female: you are not pregnant, not trying to get pregnant, and not breastfeeding
- You do not have a history of developing raised, thick scars (keloids)
- You do not have a significant nerve or muscle disease (for example ALS, motor neuropathy, myasthenia gravis, or related conditions)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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