Blood product to help jawbone healing after surgery
Part of Blood & lymphatic, Mouth & dental clinical trials.
This trial tests whether using a special blood product (leukocyte- and platelet-rich fibrin, or L-PRF) during surgery for a jawbone condition called MRONJ helps improve healing. Patients who need surgery under general anesthesia for advanced MRONJ may be able to join.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a jawbone problem called MRONJ and need surgery for it (stage 2 or 3, or a piece of dead bone needs to be removed).
- The surgery is scheduled to be done under general anesthesia (you'll be completely asleep).
- You are covered by a social security or health insurance plan in France.
- You do not have a cancerous tumor in your jaw or face.
- You have only one area of jawbone problem (not multiple).
- You have not had radiation therapy to your head or neck before.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests whether putting a special blood concentrate from your own platelets into the tooth socket after an extraction helps the bone heal better and prevent a serious jaw condition (MRONJ) in people at high risk due to certain medications like bisphosphonates or denosumab.
This study tests whether a special blood product called L-PRF can help prevent serious bone problems that sometimes happen after tooth extraction in patients who received head-and-neck radiation or took bone-related medications. The trial follows participants for 12 months to see if L-PRF helps their extraction sites heal better.
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