Testing new treatment for acute brain injury after a fall or hit
Treatments studied
Part of Brain & nervous system, Injuries & trauma clinical trials.
This study tests an investigational treatment to improve outcomes after a recent non-penetrating traumatic brain injury (like a fall or car crash). It uses early CT/MRI imaging and a blood test soon after injury to see who benefits and how well the treatment works.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be an adult age 18 to 65
- Have a non-penetrating head injury evaluated at a participating site and get the first study dose within 24 hours
- Have moderate initial symptoms, with a Glasgow Coma Scale score of 9 to 15
- Have an abnormal finding on a non-contrast head CT (like bleeding or bruising in the brain)
- Have a blood test (GFAP) level higher than 100 pg/mL but no more than 15,000 pg/mL
- Be able to have MRI and take study capsules by mouth (no swallowing problems), and follow all follow-up visits
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study is looking at people with traumatic brain injuries to improve how they are treated. If you join, you will get an MRI and other tests within the first two days after your injury, and the researchers will track your recovery over time.
This study tests a drug called cyclosporine to see if it can help people with moderate to severe traumatic brain injury. You may be eligible if you have a brain injury seen on CT and can start treatment within 24 hours.
This study tests a drug called Angiotensin (1-7) to see if it helps people recover from moderate to severe traumatic brain injury. It may reduce damage and improve healing when given shortly after the injury.
This study tests whether an anti-bleeding medicine (given to reduce unwanted clot breakdown) can improve outcomes after a mild head injury in people 50 and older. It is looking for patients who arrive quickly after injury and have certain symptoms like brief loss of consciousness, confusion, or nausea.
This study follows people with a moderate, non-penetrating traumatic brain injury (TBI) to see how small blood-vessel damage changes over time. It uses brain scans to learn what happens after a serious accident, which may help improve future care.
This trial tests whether a medicine called memantine can help the brain heal after a mild or moderate head injury. It aims to improve recovery by protecting brain blood vessels and nerve cells.
Hear when a new Traumatic Brain Injury trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.