Dexmedetomidine to prevent delirium after open-heart surgery
Treatments studied
Part of Brain & nervous system, Mental health clinical trials.
This trial tests whether a sedating medicine called dexmedetomidine can reduce the risk of “delirium” (sudden confusion) in the intensive care unit after open-heart surgery. If you’re having certain heart operations, it may help protect your thinking and alertness during recovery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are scheduled for open-heart surgery that uses a heart-lung machine (cardiopulmonary bypass).
- You are having one of these surgeries: bypass (CABG), valve repair/replacement, or a combined surgery.
- Your heart pumping strength (left ventricular ejection fraction) is more than 40%.
- You do NOT have atrial fibrillation before surgery.
- You do NOT have certain slow heart rhythm problems (second/third-degree AV block, or resting heart rate ≤ 50).
- You do NOT have a pacemaker, major kidney/liver problems, or an emergency surgery plan.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial looks at whether a medication called dexmedetomidine can reduce “postoperative delirium,” a temporary period of confusion after awake brain surgery. If you have the type of surgery the study focuses on, this could help your recovery and mental clarity afterward.
This study tests whether a medicine called dexmedetomidine, given after heart surgery, can help prevent confusion and thinking problems in older adults during their intensive care stay. If you are 60 or older and having heart surgery with a heart-lung machine, this trial might be for you.
This study looks at how a sleep medicine called dexmedetomidine affects thinking and memory after heart surgery. It compares cognitive outcomes over time to see if this sedation choice changes long-term brain function.
This trial tests whether a drug called dexmedetomidine, given during general anesthesia, helps keep your heart rate and blood pressure stable during outpatient surgery. It may be an option if you are having a minor surgery and are not on certain heart medications.
This study compares two sedative medications (remimazolam and dexmedetomidine) to see which one better prevents confusion or disorientation (called delirium) after heart surgery. Participants receive one of the two medicines during their operation, and researchers monitor them for signs of delirium during recovery.
This trial tests if a calming medicine (dexmedetomidine) given during and after brain tumor surgery can help prevent confusion or delirium afterwards.
Hear when a new Intensive Care Unit Delirium trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.