Lumateperone add-on for major depression that didn’t improve
Treatments studied
Part of Mental health clinical trials.
This study tests whether adding lumateperone to an antidepressant helps adults with major depressive disorder (MDD) who haven’t improved enough after trying at least two different antidepressants. It may help reduce depressive symptoms more than antidepressants alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re between 18 and 65 years old
- You have a diagnosis of major depression (with or without psychotic features) confirmed by an interview
- Your current depressive episode started at least 12 weeks ago and no more than 18 months ago
- Your depression scores are high at both Screening and Baseline (moderate to severe)
- You haven’t had enough improvement (less than 50%) after 2 or more antidepressant treatments during this episode, and you’ve tried one at a proper dose for at least 6 weeks
- Your symptoms do not improve too much between Screening and Baseline (no big drop in depression scores)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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