Lumateperone vs placebo for major depressive disorder
Treatments studied
Part of Mental health clinical trials.
This study tests a new medication (lumateperone) versus a placebo to see if it helps reduce symptoms of major depressive disorder. It is for people with moderate to severe depression who may be looking for a new treatment option.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with major depressive disorder (MDD) without psychotic features (such as hallucinations or delusions).
- Your depression is currently moderate to severe, as measured by a standard rating scale (MADRS score of 26 or higher).
- You have not had a significant improvement in your depression symptoms between the screening visit and the start of the treatment period.
- You have not had any serious suicidal thoughts or behavior in the past 3 to 6 months.
- You have not had a moderate to severe substance or alcohol use disorder in the last 6 months.
- You have not had major problems with sticking to previous antidepressant treatments.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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