Pacemaker versus nerve ablation for fainting due to slow heart rate
Part of Brain & nervous system clinical trials.
This trial studies treatments for a type of fainting caused by the body’s reflex slowing the heart. It compares a permanent pacemaker with a procedure called cardiac nerve ablation to see which helps prevent fainting and improves quality of life.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be older than 40 years
- Have had fainting episodes for about a year, with at least two documented events (or one fainting event that caused injury) despite standard treatments
- During a real fainting episode, testing must show a slow-heart pattern (either a pause/asystole on ECG or a specific abnormal response on a tilt test)
- Your heart rhythm on ECG should be sinus rhythm (normal rhythm starting from the sinus node)
- You must be able to have the assigned treatment per the study plan and have life expectancy of at least 12 months
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study compares a procedure called cardioneuroablation with staying on permanent pacing in people who have symptoms from a slow heart rate. It aims to see which approach works better and is safer for reducing symptoms related to sinus node or heart conduction problems.
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This study tests a procedure called cardioneuroablation, which uses targeted heat (radiofrequency) to calm overactive nerves that cause your heart to beat too slowly and make you faint. The goal is to stop severe fainting spells in people with reflex syncope who haven't gotten better with other treatments.
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