Nirogacestat for desmoid tumors with tumor growth monitoring
Treatments studied
Part of Cancer clinical trials.
This Phase 2 study tests nirogacestat (a targeted medicine) in people with desmoid tumors that are growing. It also studies how tumors respond—or don’t respond—by using repeated tumor scans and sometimes repeated tumor biopsies.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have a desmoid tumor (DT) that has grown on scans in the last 18 months, with at least one measurable tumor spot.
- Your DT is expected to benefit from treatment, and your doctor says it’s safe to wait while the tumor grows up to a limited amount.
- You can have serial tumor biopsies (more than one) and may need to provide a new tumor tissue sample.
- You’re healthy enough for treatment (blood counts, liver/kidney tests, and overall strength score are within limits).
- You can take pills by mouth and agree to pregnancy prevention during treatment and for 4 months after the last dose.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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