Nirogacestat for desmoid tumors in premenopausal women
Treatments studied
Part of Cancer clinical trials.
This trial tests a drug called nirogacestat to see if it can help premenopausal women with desmoid tumors (a type of non-cancerous growth) that are causing symptoms or getting worse. It aims to offer a new treatment option for those who need systemic therapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are a woman between 18 and 40 years old, have regular periods, and have not gone through menopause.
- You have a desmoid tumor that is causing symptoms or getting worse and needs treatment that affects your whole body.
- You are willing to use a highly effective non-hormonal birth control method and have a negative pregnancy test before starting.
- You have not taken certain other treatments for desmoid tumors (like tyrosine kinase inhibitors) within 28 days before starting.
- You do not have serious heart, liver, or stomach conditions that might interfere with the study drug.
- You are able to track your menstrual cycle and complete questionnaires.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 2 study tests whether combining cryoablation (freezing the tumor) with nirogacestat (a targeted pill treatment) can better control desmoid tumors that are growing or causing symptoms. It may help shrink tumors and improve symptoms, especially when freezing alone is challenging.
This study tests a new medication for adults with desmoid tumors (rare, slow-growing tumors that form in connective tissue). You may qualify if your tumor has grown recently, causes pain, or has come back after previous treatment.
This trial tests how safe and effective radiofrequency ablation (using heat to destroy tumor cells) is for people with desmoid tumors that are growing or causing symptoms.
This trial compares freezing the tumor (cryoablation) with standard medication for people with desmoid tumors that have grown or caused more symptoms. It aims to see which approach works better when the tumor is not in the belly.
This Phase 2 study tests nirogacestat (a targeted medicine) in people with desmoid tumors that are growing. It also studies how tumors respond—or don’t respond—by using repeated tumor scans and sometimes repeated tumor biopsies.
This trial tests a treatment called arterial embolization for desmoid tumors (non-cancerous growths) that are causing symptoms and growing. The goal is to see if blocking the blood supply to the tumor can shrink it or stop it from growing.
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