Cryoablation plus nirogacestat for progressing desmoid tumors
Treatments studied
Part of Cancer clinical trials.
This Phase 2 study tests whether combining cryoablation (freezing the tumor) with nirogacestat (a targeted pill treatment) can better control desmoid tumors that are growing or causing symptoms. It may help shrink tumors and improve symptoms, especially when freezing alone is challenging.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a confirmed desmoid tumor diagnosis on a pathology (biopsy) report.
- Your desmoid tumor is either growing over the last 12 months or causing symptoms (like worsening pain or daily activity limits).
- Your tumor must be 50% to less than 75% treatable by cryoablation in a single session, based on a scan and safety considerations.
- If you are on other desmoid treatments, you must finish them at least 28 days before starting this study (and side effects must be mostly gone).
- You must be 18 or older and able to get MRI scans, and you must be able to swallow pills.
- Your health tests (blood counts, liver/kidney function) and heart history must meet the study’s safety limits.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial compares freezing the tumor (cryoablation) with standard medication for people with desmoid tumors that have grown or caused more symptoms. It aims to see which approach works better when the tumor is not in the belly.
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