Study drug before surgery for HER2-low, HR-positive breast cancer
Treatments studied
Part of Cancer clinical trials.
This trial tests SHR-A1811 given before surgery (neoadjuvant treatment) for breast cancer that is hormone-receptor positive (HR-positive) and HER2-low. It aims to shrink or control the cancer early and see how well this approach works compared with standard care.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 70 years old
- You have not had any cancer treatment yet (no prior anti-cancer therapy or radiation, except some fully cured skin/cervix early cases)
- Your breast cancer is HR-positive, HER2-low, and Ki-67 is over 14% based on lab testing
- Your scans show no spread to distant organs (M0), and the cancer is not inflammatory
- Your general health is good enough (ECOG 0–1) and your heart/lungs and blood/organ tests are acceptable
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a combination of two targeted drugs (SHR-A1811 and pertuzumab) given before surgery to shrink HER2-positive breast cancer. It aims to see if this approach improves outcomes for patients with early-stage but high-risk disease.
This trial tests a new drug (SHR-A1811) alone or with another drug (adebrelimab) before surgery for women with a specific type of early-stage breast cancer called HR+, HER2-low. The goal is to see if this combination can shrink the tumor before surgery, possibly leading to better outcomes.
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This trial tests a new drug called SHR-A1811 combined with pertuzumab given before surgery to shrink tumors in people with early or locally advanced, hormone receptor-positive and HER2-positive breast cancer. It is designed to see if this combination can help reduce tumor size better.
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