Guided medicine weaning for low blood pressure after heart surgery
Part of Heart & circulation clinical trials.
This study tests a method to safely reduce (wean) norepinephrine, a blood-pressure–support medicine, in people who develop low blood pressure after heart surgery. It uses a monitoring index to help decide when it may be safer to lower the dose, aiming to improve recovery and reduce risks.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are older than 18 years
- You are scheduled for heart surgery soon (within 48 hours)
- After surgery, you start norepinephrine for low blood pressure from vasoplegic shock
- You have been on norepinephrine with stable blood pressure (MAP above 65) for over 4 hours
- Your blood pressure is monitored through an arterial line (radial or femoral catheter)
- You can consent to the study before surgery
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether a 5 microgram or a 10 microgram dose of norepinephrine works better to treat low blood pressure that happens after starting anesthesia or during emergency abdominal surgery. It may help doctors choose the right dose to keep your blood pressure stable.
This trial tests whether vasopressin (a medication that tightens blood vessels) works better than norepinephrine for managing blood pressure after pulmonary endarterectomy surgery, which removes blood clots from the lungs. The goal is to find the safest, most effective blood-pressure support during recovery.
This trial compares two medications, vasopressin and noradrenaline, to see which one works better at raising blood pressure in patients who develop dangerously low blood pressure (vasoplegic syndrome) within the first day after heart surgery. The goal is to find the safest and most effective treatment to stabilize blood pressure and help recovery.
This study tests whether a drug called norepinephrine can safely treat a drop in blood pressure that can happen during general anesthesia in people with chronic heart failure. It focuses on patients whose heart's pumping ability is weakened (ejection fraction 40% or less) and who are having planned surgery.
This trial tests whether noradrenaline is better than standard care for preventing dangerously low blood pressure during surgery. If you are having non-cardiac surgery that lasts at least an hour and are expected to stay overnight, this study may be for you.
This study looks at a new way to guide how safely doctors can reduce the strong blood pressure medicine (norepinephrine) in ICU patients with septic shock. Participants must be on a ventilator and have stable blood pressure and heart function.
Hear when a new Vasoplegia trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.