Modified stem cells and CAR T cells for hard-to-treat AML
Part of Blood & lymphatic, Cancer clinical trials.
This trial tests a new approach for people with acute myeloid leukemia (AML) that has not gotten better with standard treatments. First, you receive modified stem cells, then specially designed immune cells (CAR T cells) that target a protein called CD33 on leukemia cells. The goal is to see if this combination can safely help your body fight the leukemia.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- Your AML has not responded to other treatments, or has come back after a stem cell transplant.
- You have a suitable stem cell donor available.
- Your heart, kidneys, liver, and lungs are working well enough (tests will be done to check).
- You are able to care for yourself (ECOG performance status 0 or 1) and not pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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