Denosumab for adult fibrous bone lesions with ongoing pain
Treatments studied
Part of Bones, joints & muscles clinical trials.
This trial studies denosumab to reduce pain and active bone disease in adults with fibrous dysplasia / McCune-Albright syndrome. You may be eligible if your FD/MAS is causing persistent pain and has signs of active bone turnover, despite adequate pain treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re age 18 or older and have a confirmed diagnosis of fibrous dysplasia (FD) or McCune-Albright syndrome (MAS)
- Your pain is coming from an FD area and is not responding to adequate pain treatment, and it’s not mainly from a mechanical problem like an impending fracture
- Your FD pain is moderate to severe (VAS pain score 4 or higher, based on average or worst pain)
- Your doctor has evidence your FD is “actively active,” such as blood bone-turnover tests being high or scans showing increased activity in at least one lesion
- Your calcium, parathyroid hormone, and vitamin D levels are in the normal range (vitamin D supplements are allowed); hypophosphatemia must be treated (more than 0.7 on two separate tests)
- Your dental health is good (a dental check within the last 12 months)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study follows patients with fibrous dysplasia (a condition where normal bone is replaced by fibrous tissue) or McCune-Albright syndrome (a genetic condition affecting bone, skin, and hormones) to understand how these conditions develop and progress over time. There is no experimental treatment; researchers simply want to learn more about these rare conditions.
This trial tests if denosumab, a drug that strengthens bones, can help people with type 2 diabetes who have a high risk of breaking a bone. It is for patients who have had diabetes for a long time or have certain complications.
This study tests whether denosumab, a medication that strengthens bones, can also improve muscle strength and insulin sensitivity in postmenopausal women with type 2 diabetes who take metformin.
This study tests whether adding denosumab (a bone-strengthening medication) to immunotherapy helps patients with liver cancer that has spread to their bones. Denosumab may help reduce bone pain and prevent fractures while the immunotherapy fights the cancer.
This study tests a new form of calcium (amorphous calcium carbonate) to see if it can improve bone density in postmenopausal women with osteoporosis. It may offer an alternative for women who cannot or choose not to take other osteoporosis medications.
This study tests whether a drug called Denosumab, which is used to treat bone loss, can also help improve muscle strength and mass in older adults who have both osteoporosis and sarcopenia. If you qualify, you would receive the drug and be monitored over time to see if it helps your bones and muscles.
Hear when a new Fibrous Dysplasia trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.