Denosumab for adult fibrous bone lesions with ongoing pain
Treatments studied
Part of Bones, joints & muscles clinical trials.
This trial studies denosumab to reduce pain and active bone disease in adults with fibrous dysplasia / McCune-Albright syndrome. You may be eligible if your FD/MAS is causing persistent pain and has signs of active bone turnover, despite adequate pain treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re age 18 or older and have a confirmed diagnosis of fibrous dysplasia (FD) or McCune-Albright syndrome (MAS)
- Your pain is coming from an FD area and is not responding to adequate pain treatment, and it’s not mainly from a mechanical problem like an impending fracture
- Your FD pain is moderate to severe (VAS pain score 4 or higher, based on average or worst pain)
- Your doctor has evidence your FD is “actively active,” such as blood bone-turnover tests being high or scans showing increased activity in at least one lesion
- Your calcium, parathyroid hormone, and vitamin D levels are in the normal range (vitamin D supplements are allowed); hypophosphatemia must be treated (more than 0.7 on two separate tests)
- Your dental health is good (a dental check within the last 12 months)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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