Six-week medicine boost for bipolar depression after first treatment fails
Treatments studied
Part of Mental health clinical trials.
This trial tests whether a stronger, more active medication plan for six weeks helps people with bipolar depression who did not improve with their first prescribed treatment. It compares the intensified medication plan to usual care to see which approach works better.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old, and you can join as an in-patient or out-patient.
- You can sign consent to join (or a legal guardian can help if allowed).
- You have a diagnosis of bipolar depression and are currently in a depressive episode.
- Your current medicine for this episode did not work well enough, and you want to switch medicines.
- Your depression symptoms are at least moderate (MADRS score of 20 or higher), and you have daily life impact (Sheehan Disability scale score of 5 or higher).
- If you are pregnant/breastfeeding, you cannot join; if you can get pregnant, you must use effective birth control and have a negative pregnancy test before randomization.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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