Treatment
Lithium clinical trials
We’re tracking 21 recruiting studies that include Lithium, each written for real people, not researchers, below.
Recruiting studies
- NCT07540338RecruitingPhase 1/Phase 2
New Lithium Capsule Study for Bipolar I
This study compares a new lithium capsule (AL001) to a standard lithium capsule in people with Bipolar I Disorder. It aims to see how well your body absorbs each capsule and whether AL001 is safer or more tolerable.
Boston, MassachusettsAges 18–65 - NCT06592014Enrolling by invitationPhase 1/Phase 2
Lithium for Parkinson's: an extension trial
This trial extends a previous study to see if lithium can help Parkinson's symptoms. It's for people who already took part in a related study at the University at Buffalo.
Williamsville, New YorkAges 45–80 - NCT05878730Recruiting
Melatonin study for people stable on long-term lithium
This trial tests whether taking melatonin (a sleep-related hormone) changes how your body responds to lithium in people with bipolar disorder who are currently stable. It may help researchers understand lithium’s effects and how sleep/circadian timing could matter.
Paris, Île-de-France RegionAges 18–70 - NCT05593627RecruitingPhase 4
Lithium to improve sleep and thinking after heart surgery
This trial tests whether lithium carbonate can improve sleep and thinking (cognitive function) after heart valve surgery that uses a heart-lung machine. It may help some people who have trouble sleeping or thinking after surgery, but it excludes people with significant sleep or thinking problems before surgery.
Shenyang, LiaoningAges 18–65 - NCT06776848RecruitingPhase 1/Phase 2
Lithium for TBR1-related neurodevelopmental disorder
This trial tests whether taking lithium for 2 years can improve symptoms in people with a TBR1 gene change that causes neurodevelopmental challenges. It aims to see if lithium is safe and helpful for this condition.
DijonAges 6 years+ - NCT07113873Recruiting
Comparing two types of ultra-white dental veneers for appearance and patient comfort
This trial tests two different materials for dental veneers—ultra-translucent zirconia and lithium disilicate—to see which one patients prefer and how well they work. If you are between 18 and 50, have good oral health, and need veneers to fix gaps, slight color issues, or tooth shape, this study may be a good fit.
CairoAges 18–50 - NCT07157410Recruiting
Tooth-colored onlays for cavities below the gum line
This trial tests a tooth-colored filling (onlay) for back teeth with cavities that go below the gum line. It is designed for people whose tooth is weakened but still healthy enough to avoid more serious treatments like root canals.
Al Mansurah, Dakahlia GovernorateAges 20–50 - NCT05913947RecruitingPhase 4
Lithium or cariprazine for bipolar depression
This trial compares lithium versus cariprazine to treat an episode of depression in people with bipolar disorder. It may help find which medicine works better and is safer during the acute (active) phase of depression.
AalborgAges 18–65 - NCT06051240RecruitingPhase 2
Lithium to prevent thinking problems after brain radiation
This study tests if the drug lithium can help prevent memory and thinking problems that sometimes happen after brain radiation for a brain tumor. You may qualify if you are under 18 when treated and had radiation within the last 7 years.
Solna, Stockholm CountyAges 5 years+ - NCT06134349Recruiting
Bipolar Lithium Imaging Scan Study
This study uses MRI scans to look at how lithium affects the brain in people with bipolar disorder. It may help researchers understand why lithium works and how to use it better.
Leiden, South HollandAges 18 years+ - NCT06184581RecruitingPhase 4
Lithium vs lamotrigine for bipolar II disorder
This trial compares lithium and lamotrigine to see which is better for treating bipolar II disorder. You could get one of these two medicines to help manage your mood swings.
CopenhagenAges 18–70 - NCT06789783RecruitingPhase 2/Phase 3
Lithium treatment for Cornelia de Lange syndrome
This trial tests whether lithium can help people with Cornelia de Lange syndrome (CdLS) who have a confirmed NIPBL gene mutation. It might improve their daily life and overall well-being.
Milan, MIAges 4 years+ - NCT07167563Recruiting
Real-world lithium study for bipolar disorder
This study looks at how lithium works in everyday life for people with bipolar disorder. It aims to learn about real-world treatment patterns and outcomes.
AarhusAges 18 years+ - NCT05814640RecruitingPhase 1/Phase 2
STAR-AD: Testing stepwise treatment for teen depression
This trial tests a step-by-step approach to treating moderate-to-severe depression in teens. It may help find a treatment path that improves mood while keeping care safe, including for some teens who have suicidal thoughts but do not need inpatient care.
Chongqing, ProvinceAges 13–18 - NCT06929273RecruitingPhase 3
Long-term safety study of KarXT for bipolar I mania
This study tests the long-term safety of KarXT for people with bipolar I disorder who are having a manic or mixed episode. It is for people who either completed a previous KarXT study or are new to the study and have moderate to severe mania symptoms.
Glendale, ArizonaAges 18–65 - NCT05409794Recruiting
Testing blood lithium levels in people with depression and suicidality
This study checks how much lithium is naturally present in the blood and whether that relates to suicidal thoughts or attempts in people with a current major depressive episode. It may help researchers understand biological factors linked to suicide risk and improve future prevention.
MontpellierAges 18 years+ - NCT05603104RecruitingPhase 3
Medication intensification after first treatment failure in mood and psychosis
This Phase 3 study tests a stronger medication approach after your first current treatment hasn’t worked well enough. It targets people with schizophrenia, major depressive disorder, or bipolar depression who still have significant symptoms and life impact.
Ramat GanAges 18–70 - NCT05973786RecruitingPhase 3
Six-week medicine boost for bipolar depression after first treatment fails
This trial tests whether a stronger, more active medication plan for six weeks helps people with bipolar depression who did not improve with their first prescribed treatment. It compares the intensified medication plan to usual care to see which approach works better.
InnsbruckAges 18 years+ - NCT06554041Recruiting
How gum tissue reacts to different dental crown materials
This study compares how different dental crown materials affect your gums around dental implants. It may help you if you have several missing teeth and already have healed implants in good bone.
VilniusAges 18 years+ - NCT07140913RecruitingPhase 3
Testing KarXT for bipolar I mania with mood stabilizers
This study tests whether adding KarXT to lithium, valproate, or lamotrigine helps calm manic episodes in people with bipolar I disorder. It aims to see if the combination is safe and works better than the mood stabilizer alone.
Bentonville, ArkansasAges 18–65 - NCT00025935Recruiting
Brain Function Studies in Youth With Mood and Attention Disorders
This research study examines how the brains of children and teenagers with mood problems (like persistent irritability or depression) or attention difficulties work differently. Researchers use brain scans and tasks to understand these conditions better and track changes as young people grow up.
Bethesda, MarylandAges 7–60
What Lithium is being studied for
Conditions with recruiting Lithium studies.
Common questions
- Are there clinical trials studying Lithium?
- Yes. Clin2 currently lists 21 recruiting studies that include Lithium, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Lithium trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Lithium an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Lithium or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.