Drug combo with radiation for HER2+ breast cancer spread to spinal lining
Treatments studied
Part of Brain & nervous system, Cancer, Skin clinical trials.
This trial tests a combination of three targeted drugs (tucatinib, trastuzumab, and capecitabine) along with radiation to the brain or spine for people whose HER2-positive breast cancer has spread to the lining of the brain or spinal cord. The goal is to see if this treatment is safe and effective.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have HER2-positive, HER2-mutated, or HER2-amplified breast cancer that has spread to other parts of the body.
- Cancer has spread to the lining of your brain or spinal cord (leptomeningeal disease).
- You are 18 years or older and able to do most daily activities on your own.
- Any side effects from past cancer treatments have mostly resolved (except for hair loss or mild nerve issues).
- You have not had whole-brain radiation therapy for brain metastases before.
- You have not taken tucatinib before.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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